P-Glycoprotein Altered Expression in Alzheimer's Disease : Regional Anatomic Variability

Abstract EN

We investigated the expression of P-glycoprotein (P-gp) in brain samples of Alzheimer disease (AD) and normative brains (NM).

Superior temporal cortex hippocampal and brainstem samples from 15 AD and NM brains were selected from comparable sites.

P-gp positive capillaries and β-amyloid (Aβ) senile plaques (SP) were counted.

Statistical analysis of the data was performed using nonparametric data analysis with Mann-Whitney, Kruskal-Wallis, and Spearman’s tests.

There were no significant differences in P-gp expression between superior temporal and hippocampus samples.

However, there were significant differences in P-gp expression, when comparing brainstem with both hippocampal and superior temporal samples in both conditions (P<0.012; P< 0.002 in NM cases and P<0.001; <0.001 in AD cases); the brainstem has greater P-gp expression in each case and condition.

In addition, there was a notable inverse negative correlation (P<0.01) between P-gp expression and the presence of SPs in the AD condition superior temporal cortex.

The results of this study suggest that there were significant site-dependent differences in the expression of P-gp.

There may be an increased protective role for P-gp expression against amyloid deposition in the brainstem and in the superior temporal cortex of AD brains.