P-Glycoprotein Altered Expression in Alzheimer's Disease : Regional Anatomic Variability
Joint Authors
Source
Journal of Neurodegenerative Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We investigated the expression of P-glycoprotein (P-gp) in brain samples of Alzheimer disease (AD) and normative brains (NM).
Superior temporal cortex hippocampal and brainstem samples from 15 AD and NM brains were selected from comparable sites.
P-gp positive capillaries and β-amyloid (Aβ) senile plaques (SP) were counted.
Statistical analysis of the data was performed using nonparametric data analysis with Mann-Whitney, Kruskal-Wallis, and Spearman’s tests.
There were no significant differences in P-gp expression between superior temporal and hippocampus samples.
However, there were significant differences in P-gp expression, when comparing brainstem with both hippocampal and superior temporal samples in both conditions (P<0.012; P< 0.002 in NM cases and P<0.001; <0.001 in AD cases); the brainstem has greater P-gp expression in each case and condition.
In addition, there was a notable inverse negative correlation (P<0.01) between P-gp expression and the presence of SPs in the AD condition superior temporal cortex.
The results of this study suggest that there were significant site-dependent differences in the expression of P-gp.
There may be an increased protective role for P-gp expression against amyloid deposition in the brainstem and in the superior temporal cortex of AD brains.
American Psychological Association (APA)
Jeynes, Brian& Provias, John. 2013. P-Glycoprotein Altered Expression in Alzheimer's Disease : Regional Anatomic Variability. Journal of Neurodegenerative Diseases،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458026
Modern Language Association (MLA)
Jeynes, Brian& Provias, John. P-Glycoprotein Altered Expression in Alzheimer's Disease : Regional Anatomic Variability. Journal of Neurodegenerative Diseases No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-458026
American Medical Association (AMA)
Jeynes, Brian& Provias, John. P-Glycoprotein Altered Expression in Alzheimer's Disease : Regional Anatomic Variability. Journal of Neurodegenerative Diseases. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458026
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458026