Targeting the Cellular Signaling : BRAF Inhibition and Beyond for the Treatment of Metastatic Malignant Melanoma
Joint Authors
Metzger-Filho, Otto
Ades, Felipe
Source
Dermatology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although advances in cytotoxic treatments have been obtained in several neoplasias, in metastatic melanoma there was no drug able to significantly change the natural history of the disease in the last 30 years.
In the last decade, translational research identified important mechanisms in malignant transformation, invasion, and progression.
Signaling pathways can be abnormally activated by oncogenes.
The identification of oncogenic mutated kinases implicated in this process provides an opportunity for new target therapies.
The melanoma dependence on BRAF-mutated kinase allowed the development of inhibitors that produced major responses in clinical trials.
This is the beginning of a novel class of drugs in metastatic melanoma; the identification of the transduction signaling networking and other “druggable” kinases is in active research.
In this paper, we discuss the ongoing research on cellular signaling inhibition, resistance mechanisms, and strategies to overcome treatment failure.
American Psychological Association (APA)
Ades, Felipe& Metzger-Filho, Otto. 2011. Targeting the Cellular Signaling : BRAF Inhibition and Beyond for the Treatment of Metastatic Malignant Melanoma. Dermatology Research and Practice،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458155
Modern Language Association (MLA)
Ades, Felipe& Metzger-Filho, Otto. Targeting the Cellular Signaling : BRAF Inhibition and Beyond for the Treatment of Metastatic Malignant Melanoma. Dermatology Research and Practice No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-458155
American Medical Association (AMA)
Ades, Felipe& Metzger-Filho, Otto. Targeting the Cellular Signaling : BRAF Inhibition and Beyond for the Treatment of Metastatic Malignant Melanoma. Dermatology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458155