Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations

Joint Authors

Sierks, Michael
Lopez, Patricia
Davidowitz, Eliot
Moe, James
Tian, Huilai
Emadi, Sharareh

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-09-17

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

In Alzheimer’s disease (AD), tau aggregates into fibrils and higher order neurofibrillary tangles, a key histopathological feature of AD.

However, soluble oligomeric tau species may play a more critical role in AD progression since these tau species correlate better with neuronal loss and cognitive dysfunction.

Recent studies show that extracellular oligomeric tau can inhibit memory formation and synaptic function and also transmit pathology to neighboring neurons.

However, the specific forms of oligomeric tau involved in toxicity are still unknown.

Here, we used two splice variants of recombinant human tau and generated monomeric, dimeric, and trimeric fractions of each isoform.

The composition of each fraction was verified chromatographically and also by atomic force microscopy.

The toxicity of each fraction toward both human neuroblastoma cells and cholinergic-like neurons was assessed.

Trimeric, but not monomeric or dimeric, tau oligomers of both splice variants were neurotoxic at low nanomolar concentrations.

Further characterization of tau oligomer species with disease-specific modifications and morphologies is necessary to identify the best targets for the development of biomarker and therapeutic development for AD and related tauopathies.

American Psychological Association (APA)

Tian, Huilai& Davidowitz, Eliot& Lopez, Patricia& Emadi, Sharareh& Moe, James& Sierks, Michael. 2013. Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458297

Modern Language Association (MLA)

Tian, Huilai…[et al.]. Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations. International Journal of Cell Biology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-458297

American Medical Association (AMA)

Tian, Huilai& Davidowitz, Eliot& Lopez, Patricia& Emadi, Sharareh& Moe, James& Sierks, Michael. Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458297

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-458297