β-Thalassemia Intermedia in Northern Iraq : A Single Center Experience
Joint Authors
Mohammad, Ameen M.
Omer, Sharaza Q.
al-Allawi, Nasir A. S.
Jalal, Sana D.
Markous, Raji S. D.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To investigate the molecular basis of β-thalassemia intermedia in Northern Iraq and evaluate its management practices, a total of 74 patients from 51 families were enrolled.
The patients were clinically and hematologically reevaluated, and had their β-thalassemia mutations characterized, as well as the number of α-globin genes and Xmn I Gγ −158 (C>T) polymorphism studied.
Out of 14 β-thalassemia mutations identified, the four most common were IVS-I-6 (T>C) [33.3%], IVS-II-I (G>A) [21.1%], codon 82/83(−G) [10.1%], and codon 8 (−AA) [8.1%].
The most common contributing factors to the less severe phenotype of thalassemia intermedia were found to be the inheritance of mild β-thalassemia alleles and the Xmn I polymorphism, while concomitant α-thalassemia had a limited role.
Several complications were documented including: pulmonary hypertension in 20.4%, diabetes mellitus in 1.4%, hypothyroidism in 2.9%, and heart failure in 2.7%, while no documented cases of venous thrombosis were found.
Compared to their counterparts in several Mediterranean countries, it appears that our patients were much less frequently transfused and had a lower proportion of patients who were splenectomized, on iron chelation, or hydroxycarbamide therapy.
Such practices require further scrutiny to ensure that a better level of care is provided and that growth retardation, skeletal changes, and other complications are prevented or reduced.
American Psychological Association (APA)
al-Allawi, Nasir A. S.& Jalal, Sana D.& Mohammad, Ameen M.& Omer, Sharaza Q.& Markous, Raji S. D.. 2014. β-Thalassemia Intermedia in Northern Iraq : A Single Center Experience. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458492
Modern Language Association (MLA)
al-Allawi, Nasir A. S.…[et al.]. β-Thalassemia Intermedia in Northern Iraq : A Single Center Experience. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-458492
American Medical Association (AMA)
al-Allawi, Nasir A. S.& Jalal, Sana D.& Mohammad, Ameen M.& Omer, Sharaza Q.& Markous, Raji S. D.. β-Thalassemia Intermedia in Northern Iraq : A Single Center Experience. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458492