RBP4 Gene Variants Are Associated with Insulin Resistance in Women with Previous Gestational Diabetes
Joint Authors
Saucedo, Renata
Mendoza-Lorenzo, Patricia
Zarate, Arturo
Ostrosky-Wegman, Patricia
Hernandez, Marcelino
Basurto, Lourdes
Puello, Edgardo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
This study aimed to examine possible genetic effects of some retinol binding protein-4 (RBP4) single nucleotide polymorphisms (SNPs) on the risk of gestational diabetes mellitus (GDM).
In addition, the SNPs were examined for their possible association with insulin resistance at 6 weeks after delivery.
Methods.
This was a prospective study of 100 women with GDM and 100 participants with normal gestation who were evaluated at gestational week 30 and 6 weeks postpartum.
Three SNPs of RBP4 (rs3758539, rs116736522, and rs34571439) were genotyped using TaqMan assay.
The genotype distributions between GDM patients and normal controls were analyzed using logistic regression models.
In addition, differences in clinical characteristics among subjects grouped by genotype were assessed using the analysis of covariance test.
Results.
The frequencies of the rare alleles were not significantly different between GDM patients and controls.
However, we identified two variants rs3758539 and rs34571439 associated with insulin levels and insulin resistance in women with previous GDM.
Conclusion.
Noncoding SNPs of the RBP4 gene are not associated with GDM, but two SNPs showed associations with insulin resistance and insulin levels in women with prior GDM.
Additional studies with increased sample size will be necessary in other GDM cohorts.
American Psychological Association (APA)
Saucedo, Renata& Zarate, Arturo& Basurto, Lourdes& Hernandez, Marcelino& Puello, Edgardo& Mendoza-Lorenzo, Patricia…[et al.]. 2014. RBP4 Gene Variants Are Associated with Insulin Resistance in Women with Previous Gestational Diabetes. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-458991
Modern Language Association (MLA)
Saucedo, Renata…[et al.]. RBP4 Gene Variants Are Associated with Insulin Resistance in Women with Previous Gestational Diabetes. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-458991
American Medical Association (AMA)
Saucedo, Renata& Zarate, Arturo& Basurto, Lourdes& Hernandez, Marcelino& Puello, Edgardo& Mendoza-Lorenzo, Patricia…[et al.]. RBP4 Gene Variants Are Associated with Insulin Resistance in Women with Previous Gestational Diabetes. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-458991
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458991