Proliferative Vitreoretinopathy after Eye Injuries : An Overexpression of Growth Factors and Cytokines Leading to a Retinal Keloid
Joint Authors
Duse, Sarah
Romano, Mario R.
Semeraro, Francesco
Morescalchi, Francesco
Gambicorti, Elena
Costagliola, Ciro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Eye injury is a significant disabling worldwide health problem.
Proliferative Vitreoretinopathy (PVR) is a common complication that develops in up to 40–60% of patients with an open-globe injury.
Our knowledge about the pathogenesis of PVR has improved in the last decades.
It seems that the introduction of immune cells into the vitreous, like in penetrating ocular trauma, triggers the production of growth factors and cytokines that come in contact with intra-retinal cells, like Müller cells and RPE cells.
Growth factors and cytokines drive the cellular responses leading to PVR’s development.
Knowledge of the pathobiological and pathophysiological mechanisms involved in posttraumatic PVR is increasing the possibilities of management, and it is hoped that in the future our treatment strategies will evolve, in particular adopting a multidrug approach, and become even more effective in vision recovery.
This paper reviews the current literature and clinical trial data on the pathogenesis of PVR and its correlation with ocular trauma and describes the biochemical/molecular events that will be fundamental for the development of novel treatment strategies.
This literature review included PubMed articles published from 1979 through 2013.
Only studies written in English were included.
American Psychological Association (APA)
Morescalchi, Francesco& Duse, Sarah& Gambicorti, Elena& Romano, Mario R.& Costagliola, Ciro& Semeraro, Francesco. 2013. Proliferative Vitreoretinopathy after Eye Injuries : An Overexpression of Growth Factors and Cytokines Leading to a Retinal Keloid. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-459063
Modern Language Association (MLA)
Morescalchi, Francesco…[et al.]. Proliferative Vitreoretinopathy after Eye Injuries : An Overexpression of Growth Factors and Cytokines Leading to a Retinal Keloid. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-459063
American Medical Association (AMA)
Morescalchi, Francesco& Duse, Sarah& Gambicorti, Elena& Romano, Mario R.& Costagliola, Ciro& Semeraro, Francesco. Proliferative Vitreoretinopathy after Eye Injuries : An Overexpression of Growth Factors and Cytokines Leading to a Retinal Keloid. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-459063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459063