Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications

Joint Authors

Wright, Jill F.
Zhong, Xiaotian

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-04-18

Country of Publication

Egypt

No. of Pages

19

Main Subjects

Biology

Abstract EN

Over the lifespan of therapeutic proteins, from the point of biosynthesis to the complete clearance from tested subjects, they undergo various biological modifications.

Therapeutic influences and molecular mechanisms of these modifications have been well appreciated for some while remained less understood for many.

This paper has classified these modifications into multiple categories, according to their processing locations and enzymatic involvement during the trafficking events.

It also focuses on the underlying mechanisms and structural-functional relationship between modifications and therapeutic properties.

In addition, recent advances in protein engineering, cell line engineering, and process engineering, by exploring these complex cellular processes, are discussed and summarized, for improving functional characteristics and attributes of protein-based biopharmaceutical products.

American Psychological Association (APA)

Zhong, Xiaotian& Wright, Jill F.. 2013. Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-459350

Modern Language Association (MLA)

Zhong, Xiaotian& Wright, Jill F.. Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications. International Journal of Cell Biology No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-459350

American Medical Association (AMA)

Zhong, Xiaotian& Wright, Jill F.. Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-459350

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-459350