Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications
Joint Authors
Wright, Jill F.
Zhong, Xiaotian
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Over the lifespan of therapeutic proteins, from the point of biosynthesis to the complete clearance from tested subjects, they undergo various biological modifications.
Therapeutic influences and molecular mechanisms of these modifications have been well appreciated for some while remained less understood for many.
This paper has classified these modifications into multiple categories, according to their processing locations and enzymatic involvement during the trafficking events.
It also focuses on the underlying mechanisms and structural-functional relationship between modifications and therapeutic properties.
In addition, recent advances in protein engineering, cell line engineering, and process engineering, by exploring these complex cellular processes, are discussed and summarized, for improving functional characteristics and attributes of protein-based biopharmaceutical products.
American Psychological Association (APA)
Zhong, Xiaotian& Wright, Jill F.. 2013. Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-459350
Modern Language Association (MLA)
Zhong, Xiaotian& Wright, Jill F.. Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications. International Journal of Cell Biology No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-459350
American Medical Association (AMA)
Zhong, Xiaotian& Wright, Jill F.. Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-459350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459350