![](/images/graphics-bg.png)
Immune Responses in Parkinson’s Disease : Interplay between Central and Peripheral Immune Systems
Joint Authors
Federoff, Howard J.
Su, Xiaomin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The etiology of Parkinson’s disease (PD) is complex and most likely involves numerous environmental and heritable risk factors.
Recent studies establish that central and peripheral inflammation occurs in the prodromal stage of the disease and sustains disease progression.
Aging, heritable risk factors, or environmental exposures may contribute to the initiation of central or peripheral inflammation.
One emerging hypothesis is that inflammation plays a critical role in PD neuropathology.
Increasing evidence suggest that activation of the peripheral immune system exacerbates the discordant central inflammatory response and synergistically drives neurodegeneration.
We provide an overview of current knowledge on the temporal profile of central and peripheral immune responses in PD and discuss the potential synergistic effects of the central and peripheral inflammation in disease development.
The understanding of the nature of the chronic inflammation in disease progression and the possible risk factors that contribute to altered central and peripheral immune responses will offer mechanistic insights into PD etiology and pathology and benefit the development of effective tailored therapeutics for human PD.
American Psychological Association (APA)
Su, Xiaomin& Federoff, Howard J.. 2014. Immune Responses in Parkinson’s Disease : Interplay between Central and Peripheral Immune Systems. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-459535
Modern Language Association (MLA)
Su, Xiaomin& Federoff, Howard J.. Immune Responses in Parkinson’s Disease : Interplay between Central and Peripheral Immune Systems. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-459535
American Medical Association (AMA)
Su, Xiaomin& Federoff, Howard J.. Immune Responses in Parkinson’s Disease : Interplay between Central and Peripheral Immune Systems. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-459535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459535