Elevation of sE-Selectin Levels 2–24 Months following Gestational Diabetes Is Associated with Early Cardiometabolic Risk in Nondiabetic Women
Joint Authors
Góralczyk, Barbara
Grabiec, Marek
Góralczyk, Krzysztof
Szymański, Marek
Ruszkowska, Barbara
Sokup, Alina
Rość, Danuta
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
We hypothesised that the endothelial dysfunction is associated with early glucose dysregulation and/or atherosclerosis risk factors in nondiabetic women with a previous history of gestational diabetes (pGDM).
Material/Methods.
Anthropometric parameters, glucose regulation (OGTT), insulin resistance (HOMA), lipids, biomarkers of endothelial dysfunction, and inflammation were evaluated in 85 women with pGDM and in 40 controls 2–24 months postpartum.
Results.
The pGDM group consisted of 67% normoglycemic women (pGDM-N) and 33% with prediabetic state (pGDM-P).
The BMI, waist circumference, fasting and 2 h glucose (OGTT), soluble adhesion molecules, tissue plasminogen activator antigen, high sensitivity C-reactive protein, total-, LDL-cholesterol, and triglycerides/HDL-cholesterol ratio were higher in the pGDM women compared with the controls.
After adjustment for BMI and fasting glucose, only higher triglycerides, higher TG/HDL and lower HDL-cholesterol were associated with pGDM.
The pGDM-P differed from pGDM-N for only higher triglycerides and TG/HDL.
The plasma level of sE-selectin was not independently associated with glucose concentration in pGDM group.
sE-selectin level correlated with triglycerides, TG/HDL, plasminogen activator inhibitor-1 antigen, and sICAM-1.
Conclusions.
sE-selectin level correlated with components of metabolic syndrome, but only the atherogenic lipid profile was independently associated with a previous history of GDM in nondiabetic women 2–24 months postpartum.
American Psychological Association (APA)
Sokup, Alina& Ruszkowska, Barbara& Góralczyk, Barbara& Góralczyk, Krzysztof& Szymański, Marek& Grabiec, Marek…[et al.]. 2012. Elevation of sE-Selectin Levels 2–24 Months following Gestational Diabetes Is Associated with Early Cardiometabolic Risk in Nondiabetic Women. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-459698
Modern Language Association (MLA)
Sokup, Alina…[et al.]. Elevation of sE-Selectin Levels 2–24 Months following Gestational Diabetes Is Associated with Early Cardiometabolic Risk in Nondiabetic Women. International Journal of Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-459698
American Medical Association (AMA)
Sokup, Alina& Ruszkowska, Barbara& Góralczyk, Barbara& Góralczyk, Krzysztof& Szymański, Marek& Grabiec, Marek…[et al.]. Elevation of sE-Selectin Levels 2–24 Months following Gestational Diabetes Is Associated with Early Cardiometabolic Risk in Nondiabetic Women. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-459698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459698