Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System : Is There a MicroRNA Connection?
Joint Authors
Martin, Mickey M.
Sansom, Sarah E.
Elton, Terry S.
Source
International Journal of Hypertension
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Essential hypertension is a complex disorder, caused by the interplay between many genetic variants, gene-gene interactions, and environmental factors.
Given that the renin-angiotensin system (RAS) plays an important role in blood pressure (BP) control, cardiovascular regulation, and cardiovascular remodeling, special attention has been devoted to the investigation of single-nucleotide polymorphisms (SNP) harbored in RAS genes that may be associated with hypertension and cardiovascular disease.
MicroRNAs (miRNAs) are a family of small, ∼21-nucleotide long, and nonprotein-coding RNAs that recognize target mRNAs through partial complementary elements in the 3′-untranslated region (3′-UTR) of mRNAs and inhibit gene expression by targeting mRNAs for translational repression or destabilization.
Since miRNA SNPs (miRSNPs) can create, destroy, or modify miRNA binding sites, this review focuses on the hypothesis that transcribed target SNPs harbored in RAS mRNAs, that alter miRNA gene regulation and consequently protein expression, may contribute to cardiovascular disease susceptibility.
American Psychological Association (APA)
Elton, Terry S.& Sansom, Sarah E.& Martin, Mickey M.. 2010. Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System : Is There a MicroRNA Connection?. International Journal of Hypertension،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-460030
Modern Language Association (MLA)
Elton, Terry S.…[et al.]. Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System : Is There a MicroRNA Connection?. International Journal of Hypertension No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-460030
American Medical Association (AMA)
Elton, Terry S.& Sansom, Sarah E.& Martin, Mickey M.. Cardiovascular Disease, Single Nucleotide Polymorphisms; and the Renin Angiotensin System : Is There a MicroRNA Connection?. International Journal of Hypertension. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-460030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460030