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Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages
Joint Authors
Bzowska, Małgorzata
Skalniak, Anna
Guzik, Krzysztof
Hamczyk, Magda
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Accumulation of neutrophils in the site of inflammation is a typical mechanism of innate immunity.
The accumulated neutrophils are exposed to stressogenic factors usually associated with inflammation.
Here, we studied response of human peripheral blood neutrophils subjected to short, febrile-range heat stress.
We show that 90 min heat stress slowed down the spontaneous apoptosis of neutrophils.
In the absence of typical markers of apoptosis the heat-shocked neutrophils induced antiinflammatory effect in human monocyte-derived macrophages (hMDMs), yet without being engulfed.
Importantly, the expression of FcγRIII (CD16) was sharply reduced.
Surprisingly, concentration of the soluble CD16 did not change in heat-shocked neutrophil supernates indicating that the reduction of the cell surface CD16 was achieved mainly by inhibition of fresh CD16 delivery.
Inhibitors of 90 kDa heat shock protein (HSP90), a molecular chaperone found in membrane platforms together with CD16 and CD11b, significantly increased the observed effects caused by heat shock.
The presented data suggest a novel systemic aspect of increased temperature which relies on immediate modification by heat of a neutrophil molecular pattern.
This effect precedes cell death and may be beneficial in the initial phase of inflammation providing a nonphlogistic signal to macrophages before it comes from apoptotic cells.
American Psychological Association (APA)
Bzowska, Małgorzata& Hamczyk, Magda& Skalniak, Anna& Guzik, Krzysztof. 2011. Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-460307
Modern Language Association (MLA)
Bzowska, Małgorzata…[et al.]. Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-460307
American Medical Association (AMA)
Bzowska, Małgorzata& Hamczyk, Magda& Skalniak, Anna& Guzik, Krzysztof. Rapid Decrease of CD16 (FcγRIII) Expression on Heat-Shocked Neutrophils and Their Recognition by Macrophages. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-460307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460307