Pretreatment Thrombocytosis as a Prognostic Factor in Metastatic Breast Cancer
Joint Authors
Stravodimou, Athina
Voutsadakis, Ioannis A.
Source
International Journal of Breast Cancer
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
An elevated platelet count is often associated with malignancies, and it has been confirmed as an adverse prognostic factor in various cancers including early stage breast cancer.
We sought to determine if thrombocytosis is also a prognostic factor in metastatic breast cancer.
Patients and Methods.
The records of 165 metastatic breast cancer patients with complete follow-up that had thrombocytosis or normal platelet counts were reviewed.
Kaplan-Meier curves were constructed, and the survivals of the two groups were compared using the LogRank test.
A Cox regression analysis was used to determine if thrombocytosis is an independent factor for overall and progression free survival.
Results.
There was a statistically significant difference in overall and progression free survival favoring the normal platelets group (LogRank test P=0.038 and 0.008, resp.).
Thrombocytosis remained a significant adverse prognostic factor in multivariate analysis.
Other independent prognostic factors for overall survival included age, ER/PR status, and grade.
Conclusion.
Thrombocytosis represents an independent adverse prognostic factor in patients with metastatic breast cancer.
Thus metastatic breast cancer joins a range of cancers in which this easily measurable value can be used for clinical prognostication.
Further use as a predictive value for specific treatments has a rationale and deserves to be investigated.
American Psychological Association (APA)
Stravodimou, Athina& Voutsadakis, Ioannis A.. 2013. Pretreatment Thrombocytosis as a Prognostic Factor in Metastatic Breast Cancer. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460675
Modern Language Association (MLA)
Stravodimou, Athina& Voutsadakis, Ioannis A.. Pretreatment Thrombocytosis as a Prognostic Factor in Metastatic Breast Cancer. International Journal of Breast Cancer No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-460675
American Medical Association (AMA)
Stravodimou, Athina& Voutsadakis, Ioannis A.. Pretreatment Thrombocytosis as a Prognostic Factor in Metastatic Breast Cancer. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460675