Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balbc Mice

Joint Authors

Zdanowski, R.
Skopiński, Piotr
Stankiewicz, W.
Bałan, B. J.
Niemcewicz, M.
Skopińska-Różewska, Ewa
Lewicki, S.
Gawrychowski, Krzysztof
Kocik, J.

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-06-27

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Anticancer activity of many herbs was observed for hundreds of years.

They act as modifiers of biologic response, and their effectiveness may be increased by combining multiple herbal extracts .

PERVIVO, traditional digestive herbal remedy, contains some of them, and we previously described its antiangiogenic activity.

Numerous studies documented anticancer effects of nonsteroidal anti-inflammatory drugs.

We were the first to show that sulindac and its metabolites inhibit angiogenesis.

In the present paper the combined in vivo effect of multicomponent herbal remedy PERVIVO and nonsteroidal anti-inflammatory drug sulindac on tumor growth, tumor angiogenesis, and tumor volume in Balb/c mice was studied.

These effects were checked after grafting cells collected from syngeneic sarcoma L-1 tumors into mice skin.

The strongest inhibitory effect was observed in experimental groups treated with PERVIVO and sulindac together.

The results of our investigation showed that combined effect of examined drugs may be the best way to get the strongest antiangiogenic and antitumor effect.

American Psychological Association (APA)

Skopiński, Piotr& Bałan, B. J.& Kocik, J.& Zdanowski, R.& Lewicki, S.& Niemcewicz, M.…[et al.]. 2013. Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balbc Mice. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-460700

Modern Language Association (MLA)

Skopiński, Piotr…[et al.]. Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balbc Mice. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-460700

American Medical Association (AMA)

Skopiński, Piotr& Bałan, B. J.& Kocik, J.& Zdanowski, R.& Lewicki, S.& Niemcewicz, M.…[et al.]. Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balbc Mice. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-460700

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-460700