Electroacupuncture Inhibits Inflammation Reaction by Upregulating Vasoactive Intestinal Peptide in Rats with Adjuvant-Induced Arthritis
Joint Authors
He, Tian-Feng
Zhang, Chun-Yan
Chen, Yun-Fei
Li, Lian-Bo
Zhang, Shu-hui
Yang, Wen-Jia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acupuncture is emerging as an alternative therapy for rheumatoid arthritis (RA).
However, the molecular mechanism underlying this beneficial effect of acupuncture has not been fully understood.
Here, we demonstrated that electroacupuncture at acupoints Zusanli (ST36), Xuanzhong (GB39); and Shenshu (BL23) markedly decreased the paw swelling and the histologic scores of inflammation in the synovial tissue, and reduced the body weight loss in an adjuvant-induced arthritis rat model.
However, the electrical stimulation at nonacupoint did not produce any beneficial effects against the experimental arthritis.
Most interestingly, the electroacupuncture treatment resulted in an enhanced immunostaining for vasoactive intestinal peptide (VIP), a potent anti-inflammatory neuropeptide, in the synovial tissue.
Moreover, the VIP-immunostaining intensity was significantly negatively correlated with the scores of inflammation in the synovial tissue (r=−0.483, P=.0026).
In conclusion, these findings suggest that electroacupuncture may offer therapeutic benefits for the treatment of RA, at least partially through the induction of VIP expression.
American Psychological Association (APA)
He, Tian-Feng& Yang, Wen-Jia& Zhang, Shu-hui& Zhang, Chun-Yan& Li, Lian-Bo& Chen, Yun-Fei. 2010. Electroacupuncture Inhibits Inflammation Reaction by Upregulating Vasoactive Intestinal Peptide in Rats with Adjuvant-Induced Arthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-460755
Modern Language Association (MLA)
He, Tian-Feng…[et al.]. Electroacupuncture Inhibits Inflammation Reaction by Upregulating Vasoactive Intestinal Peptide in Rats with Adjuvant-Induced Arthritis. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-460755
American Medical Association (AMA)
He, Tian-Feng& Yang, Wen-Jia& Zhang, Shu-hui& Zhang, Chun-Yan& Li, Lian-Bo& Chen, Yun-Fei. Electroacupuncture Inhibits Inflammation Reaction by Upregulating Vasoactive Intestinal Peptide in Rats with Adjuvant-Induced Arthritis. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-460755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460755