A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24
Joint Authors
Mazhar, Nejat
al-Tassan, Nada
Tahir, Asma I.
Muiya, Nzioka P.
Meyer, Brian F.
al-Najai, Mohammed
Alshahid, Maie
Dzimiri, Nduna
Wakil, Salma M.
Andres, Editha
Baz, Batoul
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We examined the role of hepatic nuclear factor-1 alpha (HNF1a) gene polymorphism on coronary artery disease (CAD) traits in 4631 Saudi angiographed individuals (2419 CAD versus 2212 controls) using TaqMan assay on ABI Prism 7900HT sequence detection system.
Following adjustment for confounders, the rs2259820_CC (1.19 (1.01–1.42); P=0.041), rs2464196_TT (1.19 (1.00–1.40); P=0.045), and rs2259816_T (1.13 (1.01–1.26); P=0.031) were associated with MI.
The rs2259820_T (1.14 (1.03–1.26); P=0.011) and rs2464196_C (1.12 (1.02–1.24); P=0.024) were associated with type 2 diabetes mellitus (T2DM), while the rs2393791_T (1.14 (1.01–1.28); P=0.032), rs7310409_G (1.16 (1.03–1.30); P=0.013), and rs2464196_AG+GG (1.25 (1.05–1.49); P=0.012) were implicated in hypertension.
Hypertriglyceridemia was linked to the rs2393791_T (1.14 (1.02–1.27); P=0.018), rs7310409_G (1.12 (1.01–1.25); P=0.031), rs1169310_G (1.15 (1.04–1.28); P=0.010), and rs1169313_CT+TT (1.24 (1.06–1.45); P=0.008) and high low density lipoprotein-cholesterol levels were associated with rs2259820_T (1.23 (1.07–1.41); P=0.004), rs2464196_T (1.22 (1.06–1.39); P=0.004), and rs2259816_T (1.18 (1.02–1.36); P=0.023).
A 7-mer haplotype CATATAC (χ2=7.50; P=0.0062), constructed from the studied SNPs, was associated with MI, and CATATA implicated in T2DM (χ2=3.94; P=0.047).
Hypertriglyceridemia was linked to TGCGGG (χ2=4.26; P=0.039), and obesity to ACGGGT (χ2=5.04; P=0.025).
Our results suggest that the HNF1a is a common susceptibility gene for MI, T2DM, hypertension, and dyslipidemia.
American Psychological Association (APA)
Wakil, Salma M.& Muiya, Nzioka P.& Tahir, Asma I.& al-Najai, Mohammed& Baz, Batoul& Andres, Editha…[et al.]. 2014. A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24. Disease Markers،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-460864
Modern Language Association (MLA)
Wakil, Salma M.…[et al.]. A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24. Disease Markers No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-460864
American Medical Association (AMA)
Wakil, Salma M.& Muiya, Nzioka P.& Tahir, Asma I.& al-Najai, Mohammed& Baz, Batoul& Andres, Editha…[et al.]. A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-460864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460864