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Transgenic Rat Model of Huntington’s Disease : A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients
Joint Authors
Němečková, Ivana
Bezrouk, Aleš
Anderova, Miroslava
Mazurová, Yvona
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Rats transgenic for Huntington’s disease (tgHD51 CAG rats), surviving up to two years, represent an animal model of HD similar to the late-onset form of human disease.
This enables us to follow histopathological changes in course of neurodegenerative process (NDP) within the striatum and compare them with postmortem samples of human HD brains.
A basic difference between HD pathology in human and tgHD51 rats is in the rate of NDP progression that originates primarily from slow neuronal degeneration consequently resulting in lesser extent of concomitant reactive gliosis in the brain of tgHD51 rats.
Although larger amount of striatal neurons displays only gradual decrease in their size, their number is significantly reduced in the oldest tgHD51 rats.
Our quantitative analysis proved that the end of the first year represents the turn in the development of morphological changes related to the progression of NDP in tgHD51 rats.
Our data also support the view that all types of CNS glial cells play an important, irreplaceable role in NDP.
To the best of our knowledge, our findings are the first to document that tgHD51 CAG rats can be used as a valid animal model for detailed histopathological studies related to HD in human.
American Psychological Association (APA)
Mazurová, Yvona& Anderova, Miroslava& Němečková, Ivana& Bezrouk, Aleš. 2014. Transgenic Rat Model of Huntington’s Disease : A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-460879
Modern Language Association (MLA)
Mazurová, Yvona…[et al.]. Transgenic Rat Model of Huntington’s Disease : A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients. BioMed Research International No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-460879
American Medical Association (AMA)
Mazurová, Yvona& Anderova, Miroslava& Němečková, Ivana& Bezrouk, Aleš. Transgenic Rat Model of Huntington’s Disease : A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-460879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460879