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Crosstalk between p53 and TGF-β Signalling
Joint Authors
Inman, Gareth J.
Elston, Rebecca
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Wild-type p53 and TGF-β are key tumour suppressors which regulate an array of cellular responses.
TGF-β signals in part via the Smad signal transduction pathway.
Wild-type p53 and Smads physically interact and coordinately induce transcription of a number of key tumour suppressive genes.
Conversely mutant p53 generally subverts tumour suppressive TGF-β responses, diminishing transcriptional activation of key TGF-β target genes.
Mutant p53 can also interact with Smads and this enables complex formation with the p53 family member p63 and blocks p63-mediated activation of metastasis suppressing genes to promote tumour progression.
p53 and Smad function may also overlap during miRNA biogenesis as they can interact with the same components of the Drosha miRNA processing complex to promote maturation of specific subsets of miRNAs.
This paper investigates the crosstalk between p53 and TGF-β signalling and the potential roles this plays in cancer biology.
American Psychological Association (APA)
Elston, Rebecca& Inman, Gareth J.. 2012. Crosstalk between p53 and TGF-β Signalling. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-461105
Modern Language Association (MLA)
Elston, Rebecca& Inman, Gareth J.. Crosstalk between p53 and TGF-β Signalling. Journal of Signal Transduction No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-461105
American Medical Association (AMA)
Elston, Rebecca& Inman, Gareth J.. Crosstalk between p53 and TGF-β Signalling. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-461105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461105