Serum Fructosamine, Total Cholesterol, and High-Density Lipoprotein in Children with Asthma during Glucocorticoid Treatment
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background/Aims.
Glucocorticoids may have adverse effects on carbohydrate and lipid metabolism.
The present study was conducted to investigate possible effects on carbohydrate and lipid metabolism of inhaled and oral glucocorticoids in children with asthma.
Methods.
Two randomised controlled trials with blinded crossover designs were performed.
Active treatment was 400 μg inhaled budesonide or 5 mg prednisolone orally daily during one week.
The budesonide trial included 17 and the prednisolone trial 20 school children.
Serum fructosamine, total cholesterol and high-density lipoprotein were assessed.
Results.
Serum fructosamine was increased during active treatment (prednisolone 252.3 μM versus placebo 247.3 μM; P = 0.03 and budesonide 228.1 μM versus no treatment 223.1 μM; P = 0.02).
Total cholesterol and high-density lipoprotein were not statistically significantly increased.
Conclusion.
Short-term treatment with oral prednisolone and inhaled budesonide may adversely affect mean blood glucose concentration.
Possible long-term consequences require further investigations.
American Psychological Association (APA)
Schou, A. J.& Wolthers, Ole D.. 2011. Serum Fructosamine, Total Cholesterol, and High-Density Lipoprotein in Children with Asthma during Glucocorticoid Treatment. ISRN Allergy،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-461204
Modern Language Association (MLA)
Schou, A. J.& Wolthers, Ole D.. Serum Fructosamine, Total Cholesterol, and High-Density Lipoprotein in Children with Asthma during Glucocorticoid Treatment. ISRN Allergy No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-461204
American Medical Association (AMA)
Schou, A. J.& Wolthers, Ole D.. Serum Fructosamine, Total Cholesterol, and High-Density Lipoprotein in Children with Asthma during Glucocorticoid Treatment. ISRN Allergy. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-461204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461204