Neuropathic Pain in Animal Models of Nervous System Autoimmune Diseases

Joint Authors

Tian, David H.
Moalem-Taylor, Gila
Perera, Chamini J.

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-05-08

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Diseases

Abstract EN

Neuropathic pain is a frequent chronic presentation in autoimmune diseases of the nervous system, such as multiple sclerosis (MS) and Guillain-Barre syndrome (GBS), causing significant individual disablement and suffering.

Animal models of experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN) mimic many aspects of MS and GBS, respectively, and are well suited to study the pathophysiology of these autoimmune diseases.

However, while much attention has been devoted to curative options, research into neuropathic pain mechanisms and relief has been somewhat lacking.

Recent studies have demonstrated a variety of sensory abnormalities in different EAE and EAN models, which enable investigations of behavioural changes, underlying mechanisms, and potential pharmacotherapies for neuropathic pain associated with these diseases.

This review examines the symptoms, mechanisms, and clinical therapeutic options in these conditions and highlights the value of EAE and EAN animal models for the study of neuropathic pain in MS and GBS.

American Psychological Association (APA)

Tian, David H.& Perera, Chamini J.& Moalem-Taylor, Gila. 2013. Neuropathic Pain in Animal Models of Nervous System Autoimmune Diseases. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-461499

Modern Language Association (MLA)

Tian, David H.…[et al.]. Neuropathic Pain in Animal Models of Nervous System Autoimmune Diseases. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-461499

American Medical Association (AMA)

Tian, David H.& Perera, Chamini J.& Moalem-Taylor, Gila. Neuropathic Pain in Animal Models of Nervous System Autoimmune Diseases. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-461499

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-461499