Ferritin in Adult-Onset Still’s Disease : Just a Useful Innocent Bystander?
Joint Authors
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Adult-Onset Still’s Disease (AOSD) is an immune-mediated systemic disease with quotidian-spiking fever, rash, and inflammatory arthritis.
Hyperferritinemia is a prominent feature, often used for screening.
Methods.
The key terms “ferritin” and “hyperferritinemia” were used to search PubMed and Medline and were cross-referenced with “Still’s Disease.” Results.
Hyperferritinemia, although nonspecific, is particularly prevalent in AOSD.
While most clinicians associate ferritin with iron metabolism, this is mostly true for the H isoform and not for the L isoform that tends to increase dramatically in hyperferritenemia.
In these situations, hyperferritinemia is not associated with iron metabolism and may even mask an underlying iron deficiency.
We review, in systematic fashion, the current basic science and clinical literature regarding the regulation of ferritin and its use in the diagnosis and management of AOSD.
Conclusion.
Serum hyperferritinemia in AOSD has been described for 2 decades, although its mechanism has not yet been completely elucidated.
Regulation by proinflammatory cytokines such as interleukin (IL)-1b, IL-6, IL-18, MCSF, and INF-α provides a link to the disease pathogenesis and may explain rapid resolution of hyperferritinemia after targeted treatment and inhibition of key cytokines.Erratum to “Ferritin in Adult-Onset Still's Disease: Just a Useful Innocent Bystander?”dx.doi.org/10.1155/2012/254858
American Psychological Association (APA)
Mehta, Bella& Efthimiou, Petros. 2012. Ferritin in Adult-Onset Still’s Disease : Just a Useful Innocent Bystander?. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-461510
Modern Language Association (MLA)
Mehta, Bella& Efthimiou, Petros. Ferritin in Adult-Onset Still’s Disease : Just a Useful Innocent Bystander?. International Journal of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-461510
American Medical Association (AMA)
Mehta, Bella& Efthimiou, Petros. Ferritin in Adult-Onset Still’s Disease : Just a Useful Innocent Bystander?. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-461510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461510