An Evaluation of Neoadjuvant Chemoradiotherapy for Patients with Resectable Pancreatic Ductal Adenocarcinoma
Joint Authors
Jiang, Hui
He, Hai
Chen, Cheng
Qiu, Jianguo
Wu, Hong
Cai, Mingwei
Du, Chi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
The aim of this study is to compare our results of preoperative chemotherapy followed by pancreaticoduodenectomy (PD) with those of surgery alone in patients with localized resectable pancreatic ductal adenocarcinoma (PDAC).
Methods.
Outcome data for 112 patients of resectable PDAC who received preoperative chemoradiotherapy followed by PD (group I) between January 2004 and April 2010 were retrospectively analyzed and were compared with selected 120 patients who underwent PD alone (group II) in the same period.
Results.
Patients in group I had an incidence of locoregional recurrence of 17.1% compared to 30.8% in group II (P=0.03).
There were no statistically significant differences in postoperative morbidity (27.7% versus 30.8%) and mortality (2.67% versus 3.33%).
The 1-, 2-, and 3-year survival rates were estimated at 82.1%, 54%, and 28%, respectively, with NCRT and 65.8%, 29.1%, and 10% without (P=0.006).
Nevertheless, preoperative chemotherapy did not reduce the 1-, 3-, and 5-year disease-free survival rates, which were estimated at 58%, 36.6%, and 12.5% with NCRT and 51.7%, 18.3%, and 7.5% without (P=0.058).
Conclusions.
The treatment of NCRT followed by PD in patients with PDAC has a significantly lower rate of locoregional recurrence and a longer overall survival than those with surgery alone.
American Psychological Association (APA)
Jiang, Hui& Du, Chi& Cai, Mingwei& He, Hai& Chen, Cheng& Qiu, Jianguo…[et al.]. 2013. An Evaluation of Neoadjuvant Chemoradiotherapy for Patients with Resectable Pancreatic Ductal Adenocarcinoma. HPB Surgery،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461538
Modern Language Association (MLA)
Jiang, Hui…[et al.]. An Evaluation of Neoadjuvant Chemoradiotherapy for Patients with Resectable Pancreatic Ductal Adenocarcinoma. HPB Surgery No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-461538
American Medical Association (AMA)
Jiang, Hui& Du, Chi& Cai, Mingwei& He, Hai& Chen, Cheng& Qiu, Jianguo…[et al.]. An Evaluation of Neoadjuvant Chemoradiotherapy for Patients with Resectable Pancreatic Ductal Adenocarcinoma. HPB Surgery. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461538