Potential Role of Thymosin-α1 Adjuvant Therapy for Glioblastoma
Joint Authors
de la Monte, Suzanne M.
Sungarian, Arno
Bowling, Nathaniel
Cielo, Deus
Moskal, Peter
Wands, Jack R.
Sampath, Prakash
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Glioblastomas are high-grade, malignant CNS neoplasms that are nearly always fatal within 12 months of diagnosis.
Immunotherapy using proinflammatory cytokines such as IL-2 or IL-12 may prolong survival with glioblastoma.
Thymosin-α1 (Talpha1) is a thymic hormone and immunemodulator that increase IL-2 production and T-cell proliferation.
We examined potential therapeutic effects of Talpha1 in experimental in vivo glioblastoma, and characterized Talpha1's anti-tumor effects in vitro.
Rar 9L cells (104) were implanted into the right frontal lobe of adult Long Evans rats that were subsequently treated with vehicle, BCNU, Talpha1, or Talpha1+BCNU from postoperative day 6.
Talpha1+BCNU significantly lowered tumor burdens, and increased cure rates.
In vitro experiments demonstrated that Talpha1 had no direct effect on viability or mitochondrial function, and instead, it increased expression of pro-apoptosis genes, including FasL, FasR and TNFα-R1 (65.89%, 44.08%, and 22.18%, resp.), and increased 9L cell sensitivity to oxidative stress.
Moreover, Talpha1 enhanced 9L cell sensitivity to both Granzyme B- and BCNU-mediated killing.
The findings suggest that Talpha1 enhances BCNUmediated eradication of glioblastoma in vivo, and that Talpha1 mediates its effects by activating pro-apoptosis mechanisms, rendering neoplastic cells more sensitive to oxidative stress and immune-mediated killing by Granzyme B and chemotherapeutic agents.
American Psychological Association (APA)
Sungarian, Arno& Cielo, Deus& Sampath, Prakash& Bowling, Nathaniel& Moskal, Peter& Wands, Jack R.…[et al.]. 2010. Potential Role of Thymosin-α1 Adjuvant Therapy for Glioblastoma. Journal of Oncology،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-461655
Modern Language Association (MLA)
Sungarian, Arno…[et al.]. Potential Role of Thymosin-α1 Adjuvant Therapy for Glioblastoma. Journal of Oncology No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-461655
American Medical Association (AMA)
Sungarian, Arno& Cielo, Deus& Sampath, Prakash& Bowling, Nathaniel& Moskal, Peter& Wands, Jack R.…[et al.]. Potential Role of Thymosin-α1 Adjuvant Therapy for Glioblastoma. Journal of Oncology. 2010. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-461655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461655