CSF Biomarkers of Alzheimer’s Disease : Impact on Disease Concept, Diagnosis, and Clinical Trial Design
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Data from clinicopathologic and biomarker studies have converged to support the view of Alzheimer’s disease (AD) as a continuum, with pathology developing decades prior to the onset of cognitive symptoms which culminate as dementia at the end stage of the disease.
This concept is impacting disease nomenclature, diagnostic criteria, prognostic potential, and clinical trial design.
Revisions to diagnostic criteria to incorporate biomarker results have recently been proposed in order to increase the confidence of AD as the underlying etiology of a clinical impairment and to permit a diagnosis of AD across the disease continuum, eventually perhaps in the asymptomatic period.
Individuals in this preclinical stage are receiving intense focus as a targeted population for secondary prevention trials aimed at identifying disease-modifying therapies that have the best chance of preserving normal cognitive function.
The goal is to bring validated biomarkers to clinical practice for the purpose of disease diagnosis, prognosis, and evaluation of therapeutic efficacy once disease-modifying treatments become available.
Realization of this goal requires worldwide biomarker standardization efforts, consensus among researchers and clinicians regarding the clinical utility of assessing biomarkers in patient care settings, and eventually the endorsement and adoption of such procedures and practices into global health care systems.
American Psychological Association (APA)
Fagan, Anne M.. 2014. CSF Biomarkers of Alzheimer’s Disease : Impact on Disease Concept, Diagnosis, and Clinical Trial Design. Advances in Geriatrics،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-461721
Modern Language Association (MLA)
Fagan, Anne M.. CSF Biomarkers of Alzheimer’s Disease : Impact on Disease Concept, Diagnosis, and Clinical Trial Design. Advances in Geriatrics No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-461721
American Medical Association (AMA)
Fagan, Anne M.. CSF Biomarkers of Alzheimer’s Disease : Impact on Disease Concept, Diagnosis, and Clinical Trial Design. Advances in Geriatrics. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-461721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461721