Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1 : Biodistribution and Engraftment Analysis by Bioluminescent Imaging
Joint Authors
Antonini, Annalisa
Di Rocco, Giuliana
Toietta, Gabriele
Capogrossi, Maurizio C.
Wu, Joseph C.
Gentile, Antonietta
Ceradini, Francesca
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Chronic ulcers represent a major health problem in diabetic patients resulting in pain and discomfort.
Conventional therapy does not guarantee adequate wound repair.
In diabetes, impaired healing is partly due to poor endothelial progenitor cells mobilisation and homing, with altered levels of the chemokine stromal-derived factor-1 (SDF-1) at the wound site.
Adipose tissue-associated stromal cells (AT-SCs) can provide an accessible source of progenitor cells secreting proangiogenic factors and differentiating into endothelial-like cells.
We demonstrated that topical administration of AT-SCs genetically modified ex vivo to overexpress SDF-1, promotes wound healing into diabetic mice.
In particular, by in vivo bioluminescent imaging analysis, we monitored biodistribution and survival after transplantation of luciferase-expressing cells.
In conclusion, this study indicates the therapeutic potential of AT-SCs administration in wound healing, through cell differentiation, enhanced cellular recruitment at the wound site, and paracrine effects associated with local growth-factors production.
American Psychological Association (APA)
Di Rocco, Giuliana& Gentile, Antonietta& Antonini, Annalisa& Ceradini, Francesca& Wu, Joseph C.& Capogrossi, Maurizio C.…[et al.]. 2010. Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1 : Biodistribution and Engraftment Analysis by Bioluminescent Imaging. Stem Cells International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-461869
Modern Language Association (MLA)
Di Rocco, Giuliana…[et al.]. Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1 : Biodistribution and Engraftment Analysis by Bioluminescent Imaging. Stem Cells International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-461869
American Medical Association (AMA)
Di Rocco, Giuliana& Gentile, Antonietta& Antonini, Annalisa& Ceradini, Francesca& Wu, Joseph C.& Capogrossi, Maurizio C.…[et al.]. Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1 : Biodistribution and Engraftment Analysis by Bioluminescent Imaging. Stem Cells International. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-461869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461869