Effects of β-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM2.5)
Joint Authors
Lv, Jiyuan
Gao, Yuping
Wang, Lixia
Yin, Yanping
Li, Xuewen
Lin, Yuanyuan
Liu, Yan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The pathophysiological mechanisms of heart failure (HF) stems were mainly from longstanding overactivation of the sympathetic nervous system and renin-angiotensin-aldosterone system.
Recent studies highlighted the potential benefits of β1-adrenoceptor (β1-AR) blocker combined with β2-adrenergic receptor (β2-AR) agonist in patients with HF.
Long-term exposure to fine particulate air pollution, such as particulate matter ≤ 2.5 μm in diameter (PM2.5), has been found associated with acute myocardial infarction (AMI) which is the most common cause of congestive HF.
In this study, we have investigated the effect of combined metoprolol and terbutaline on cardiac function in a rat model of AMI exposed to PM2.5.
Our results demonstrated that short-term exposure to PM2.5 contributes to aggravate cardiac function in rats with myocardial infarction.
The combined use of β1-AR blocker and β2-AR agonist is superior to β1-AR blocker alone for the treatment of AMI rats exposed to PM2.5.
The combination of β1-AR blocker and β2-AR agonist may decrease the mortality of patients with myocardial infarction who have been exposed to PM2.5.
American Psychological Association (APA)
Gao, Yuping& Lv, Jiyuan& Lin, Yuanyuan& Li, Xuewen& Wang, Lixia& Yin, Yanping…[et al.]. 2014. Effects of β-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM2.5). BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462249
Modern Language Association (MLA)
Gao, Yuping…[et al.]. Effects of β-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM2.5). BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-462249
American Medical Association (AMA)
Gao, Yuping& Lv, Jiyuan& Lin, Yuanyuan& Li, Xuewen& Wang, Lixia& Yin, Yanping…[et al.]. Effects of β-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM2.5). BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462249