Evidence of Inflammatory System Involvement in Parkinson’s Disease
Joint Authors
Chao, Yinxia
Tan, Eng King
Wong, Siew Cheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a chronic neurodegenerative disease underpinned by both genetic and environmental etiologic factors.
Recent findings suggest that inflammation may be a pathogenic factor in the onset and progression of both familial and sporadic PD.
Understanding the precise role of inflammatory factors in PD will likely lead to understanding of how the disease arises.
In vivo evidence for inflammation in PD includes dysregulated molecular mediators such as cytokines, complement system and its receptors, resident microglial activation, peripheral immune cells invasion, and altered composition and phenotype of peripheral immune cells.
The growing awareness of these factors has prompted novel approaches to modulate the immune system, although it remains whether these approaches can be used in humans.
Influences of ageing and differential exposure to environmental agents suggest potential host-pathogen specific pathophysiologic factors.
There is a clear need for research to further unravel the pathophysiologic role of immunity in PD, with the potential of developing new therapeutic targets for this debilitating condition.
American Psychological Association (APA)
Chao, Yinxia& Wong, Siew Cheng& Tan, Eng King. 2014. Evidence of Inflammatory System Involvement in Parkinson’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462294
Modern Language Association (MLA)
Chao, Yinxia…[et al.]. Evidence of Inflammatory System Involvement in Parkinson’s Disease. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-462294
American Medical Association (AMA)
Chao, Yinxia& Wong, Siew Cheng& Tan, Eng King. Evidence of Inflammatory System Involvement in Parkinson’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462294