The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis
Joint Authors
Leib, Stephen L.
Junghanss, Thomas
Coulibaly, Boubacar
Sie, Ali
Grandgirard, Denis
Dangy, Jean-Pierre
Pluschke, Gerd
Schudel, Hans
Gäumann, Rahel
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
The brain’s inflammatory response to the infecting pathogen determines the outcome of bacterial meningitis (BM), for example, the associated mortality and the extent of brain injury.
The inflammatory cascade is initiated by the presence of bacteria in the cerebrospinal fluid (CSF) activating resident immune cells and leading to the influx of blood derived leukocytes.
To elucidate the pathomechanisms behind the observed difference in outcome between different pathogens, we compared the inflammatory profile in the CSF of patients with BM caused by Streptococcus pneumonia (n=14), Neisseria meningitidis (n=22), and Haemophilus influenza (n=9).
Methods.
CSF inflammatory parameters, including cytokines and chemokines, MMP-9, and nitric oxide synthase activity, were assessed in a cohort of patients with BM from Burkina Faso.
Results.
Pneumococcal meningitis was associated with significantly higher CSF concentrations of IFN-γ, MCP-1, and the matrix-metalloproteinase (MMP-) 9.
In patients with a fatal outcome, levels of TNF-α, IL-1β, IL-1RA, IL-6, and TGF-α were significantly higher.
Conclusion.
The signature of pro- and anti-inflammatory mediators and the intensity of inflammatory processes in CSF are determined by the bacterial pathogen causing bacterial meningitis with pneumococcal meningitis being associated with a higher case fatality rate than meningitis caused by N.
meningitidis or H.
influenzae.
American Psychological Association (APA)
Grandgirard, Denis& Gäumann, Rahel& Coulibaly, Boubacar& Dangy, Jean-Pierre& Sie, Ali& Junghanss, Thomas…[et al.]. 2013. The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-462555
Modern Language Association (MLA)
Grandgirard, Denis…[et al.]. The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-462555
American Medical Association (AMA)
Grandgirard, Denis& Gäumann, Rahel& Coulibaly, Boubacar& Dangy, Jean-Pierre& Sie, Ali& Junghanss, Thomas…[et al.]. The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-462555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462555