The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis

Joint Authors

Leib, Stephen L.
Junghanss, Thomas
Coulibaly, Boubacar
Sie, Ali
Grandgirard, Denis
Dangy, Jean-Pierre
Pluschke, Gerd
Schudel, Hans
Gäumann, Rahel

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-06-20

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

Background.

The brain’s inflammatory response to the infecting pathogen determines the outcome of bacterial meningitis (BM), for example, the associated mortality and the extent of brain injury.

The inflammatory cascade is initiated by the presence of bacteria in the cerebrospinal fluid (CSF) activating resident immune cells and leading to the influx of blood derived leukocytes.

To elucidate the pathomechanisms behind the observed difference in outcome between different pathogens, we compared the inflammatory profile in the CSF of patients with BM caused by Streptococcus pneumonia (n=14), Neisseria meningitidis (n=22), and Haemophilus influenza (n=9).

Methods.

CSF inflammatory parameters, including cytokines and chemokines, MMP-9, and nitric oxide synthase activity, were assessed in a cohort of patients with BM from Burkina Faso.

Results.

Pneumococcal meningitis was associated with significantly higher CSF concentrations of IFN-γ, MCP-1, and the matrix-metalloproteinase (MMP-) 9.

In patients with a fatal outcome, levels of TNF-α, IL-1β, IL-1RA, IL-6, and TGF-α were significantly higher.

Conclusion.

The signature of pro- and anti-inflammatory mediators and the intensity of inflammatory processes in CSF are determined by the bacterial pathogen causing bacterial meningitis with pneumococcal meningitis being associated with a higher case fatality rate than meningitis caused by N.

meningitidis or H.

influenzae.

American Psychological Association (APA)

Grandgirard, Denis& Gäumann, Rahel& Coulibaly, Boubacar& Dangy, Jean-Pierre& Sie, Ali& Junghanss, Thomas…[et al.]. 2013. The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-462555

Modern Language Association (MLA)

Grandgirard, Denis…[et al.]. The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-462555

American Medical Association (AMA)

Grandgirard, Denis& Gäumann, Rahel& Coulibaly, Boubacar& Dangy, Jean-Pierre& Sie, Ali& Junghanss, Thomas…[et al.]. The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-462555

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-462555