Statins Activate Human PPARα Promoter and Increase PPARα mRNA Expression and Activation in HepG2 Cells
Joint Authors
Katayama, Shigehiro
Komoda, Tsugikazu
Nakano, Takanari
Inoue, Ikuo
Takahashi, Seiichiro
Seo, Makoto
Ikeda, Masaaki
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Statins increase peroxisome proliferator-activated receptor α (PPARα) mRNA expression, but the mechanism of this increased PPARα production remains elusive.
To examine the regulation of PPARα production, we examined the effect of 7 statins (atorvastatin, cerivastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin) on human PPARα promoter activity, mRNA expression, nuclear protein levels, and transcriptional activity.
The main results are as follows.
(1) Majority of statins enhanced PPARα promoter activity in a dose-dependent manner in HepG2 cells transfected with the human PPARα promoter.
This enhancement may be mediated by statin-induced HNF-4α.
(2) PPARα mRNA expression was increased by statin treatment.
(3) The PPARα levels in nuclear fractions were increased by statin treatment.
(4) Simvastatin, pravastatin, and cerivastatin markedly enhanced transcriptional activity in 293T cells cotransfected with acyl-coenzyme A oxidase promoter and PPARα/RXRα expression vectors.
In summary, these data demonstrate that PPARα production and activation are upregulated through the PPARα promoter activity by statin treatment.
American Psychological Association (APA)
Seo, Makoto& Inoue, Ikuo& Ikeda, Masaaki& Nakano, Takanari& Takahashi, Seiichiro& Katayama, Shigehiro…[et al.]. 2008. Statins Activate Human PPARα Promoter and Increase PPARα mRNA Expression and Activation in HepG2 Cells. PPAR Research،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-462902
Modern Language Association (MLA)
Seo, Makoto…[et al.]. Statins Activate Human PPARα Promoter and Increase PPARα mRNA Expression and Activation in HepG2 Cells. PPAR Research No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-462902
American Medical Association (AMA)
Seo, Makoto& Inoue, Ikuo& Ikeda, Masaaki& Nakano, Takanari& Takahashi, Seiichiro& Katayama, Shigehiro…[et al.]. Statins Activate Human PPARα Promoter and Increase PPARα mRNA Expression and Activation in HepG2 Cells. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-462902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462902