Disulfide Bonding in Neurodegenerative Misfolding Diseases
Author
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In recent years an increasing number of neurodegenerative diseases has been linked to the misfolding of a specific protein and its subsequent accumulation into aggregated species, often toxic to the cell.
Of all the factors that affect the behavior of these proteins, disulfide bonds are likely to be important, being very conserved in protein sequences and being the enzymes devoted to their formation among the most conserved machineries in mammals.
Their crucial role in the folding and in the function of a big fraction of the human proteome is well established.
The role of disulfide bonding in preventing and managing protein misfolding and aggregation is currently under investigation.
New insights into their involvement in neurodegenerative diseases, their effect on the process of protein misfolding and aggregation, and into the role of the cellular machineries devoted to disulfide bond formation in neurodegenerative diseases are emerging.
These studies mark a step forward in the comprehension of the biological base of neurodegenerative disorders and highlight the numerous questions that still remain open.
American Psychological Association (APA)
Mossuto, Maria Francesca. 2013. Disulfide Bonding in Neurodegenerative Misfolding Diseases. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-463092
Modern Language Association (MLA)
Mossuto, Maria Francesca. Disulfide Bonding in Neurodegenerative Misfolding Diseases. International Journal of Cell Biology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-463092
American Medical Association (AMA)
Mossuto, Maria Francesca. Disulfide Bonding in Neurodegenerative Misfolding Diseases. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-463092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463092