Disulfide Bonding in Neurodegenerative Misfolding Diseases

Author

Mossuto, Maria Francesca

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-08-01

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Biology

Abstract EN

In recent years an increasing number of neurodegenerative diseases has been linked to the misfolding of a specific protein and its subsequent accumulation into aggregated species, often toxic to the cell.

Of all the factors that affect the behavior of these proteins, disulfide bonds are likely to be important, being very conserved in protein sequences and being the enzymes devoted to their formation among the most conserved machineries in mammals.

Their crucial role in the folding and in the function of a big fraction of the human proteome is well established.

The role of disulfide bonding in preventing and managing protein misfolding and aggregation is currently under investigation.

New insights into their involvement in neurodegenerative diseases, their effect on the process of protein misfolding and aggregation, and into the role of the cellular machineries devoted to disulfide bond formation in neurodegenerative diseases are emerging.

These studies mark a step forward in the comprehension of the biological base of neurodegenerative disorders and highlight the numerous questions that still remain open.

American Psychological Association (APA)

Mossuto, Maria Francesca. 2013. Disulfide Bonding in Neurodegenerative Misfolding Diseases. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-463092

Modern Language Association (MLA)

Mossuto, Maria Francesca. Disulfide Bonding in Neurodegenerative Misfolding Diseases. International Journal of Cell Biology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-463092

American Medical Association (AMA)

Mossuto, Maria Francesca. Disulfide Bonding in Neurodegenerative Misfolding Diseases. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-463092

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-463092