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Electroacupuncture Attenuates 5′-Guanidinonaltrindole-Evoked Scratching and Spinal c-Fos Expression in the Mouse
Joint Authors
Chen, Yi-Hung
Yang, Han-Yin
Lin, Chia-Hsien
Lin, Jaung Geng
Dun, Nae J.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study was undertaken to investigate the influence of electroacupuncture (EA) on compulsive scratching in mice and c-Fos expression elicited by subcutaneous (s.c.) administration of a known puritogen, 5′-guanidinonaltrindole (GNTI) to the neck.
Application of EA to Hegu (LI4) and Quchi (LI11) acupoints at 2 Hz, but not 100 Hz, attenuated GNTI-evoked scratching.
In mice pretreated with the µ opioid receptor antagonist naloxone, EA 2 Hz did not attenuate GNTI-evoked scratching, whereas EA at 2 Hz did attenuate GNTI-evoked scratching in mice pretreated with the κ opioid receptor antagonist nor-binaltorphimine.
Moreover, intradermal (i.d.) administration of the selective µ opioid receptor agonist [d-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin acetate (DAMGO) attenuated GNTI-evoked scratching behavior, while s.c.
administration of DAMGO was ineffective.
GNTI provoked c-Fos expression on the lateral side of the superficial layer of the dorsal horn of the cervical spinal cord.
Application of 2 Hz EA to LI4 and LI11 decreased the number of c-Fos positive nuclei induced by GNTI.
It may be concluded that application of 2 Hz EA to LI4 and LI11 attenuates scratching behavior induced by GNTI in mice and that the peripheral µ opioid system is involved, at least in part, in the anti-pruritic effects of EA.
American Psychological Association (APA)
Chen, Yi-Hung& Yang, Han-Yin& Lin, Chia-Hsien& Dun, Nae J.& Lin, Jaung Geng. 2013. Electroacupuncture Attenuates 5′-Guanidinonaltrindole-Evoked Scratching and Spinal c-Fos Expression in the Mouse. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-463148
Modern Language Association (MLA)
Chen, Yi-Hung…[et al.]. Electroacupuncture Attenuates 5′-Guanidinonaltrindole-Evoked Scratching and Spinal c-Fos Expression in the Mouse. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-463148
American Medical Association (AMA)
Chen, Yi-Hung& Yang, Han-Yin& Lin, Chia-Hsien& Dun, Nae J.& Lin, Jaung Geng. Electroacupuncture Attenuates 5′-Guanidinonaltrindole-Evoked Scratching and Spinal c-Fos Expression in the Mouse. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-463148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463148