Adipo-Myokines : Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1.
It is suggested that the term myokine is restricted to proteins secreted from skeletal muscle cells, excluding proteins that are secreted by other cell types in skeletal muscle tissue and excluding proteins which are only described on the mRNA level.
Interestingly, many of the contraction-regulated myokines described in the literature are additionally known to be secreted by adipocytes.
We termed these proteins adipo-myokines.
Within this review, we try to elaborate on the question why pro-inflammatory adipokines on the one hand are upregulated in the obese state, and have beneficial effects after exercise on the other hand.
Both, adipokines and myokines do have autocrine effects within their corresponding tissues.
In addition, they are involved in an endocrine crosstalk with other tissues.
Depending on the extent and the kinetics of adipo-myokines in serum, these molecules seem to have a beneficial or an adverse effect on the target tissue.
American Psychological Association (APA)
Raschke, Silja& Eckel, Jürgen. 2013. Adipo-Myokines : Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-463294
Modern Language Association (MLA)
Raschke, Silja& Eckel, Jürgen. Adipo-Myokines : Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise. Mediators of Inflammation No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-463294
American Medical Association (AMA)
Raschke, Silja& Eckel, Jürgen. Adipo-Myokines : Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-463294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463294