Physiopathology of Bone Modifications in β-Thalassemia
Joint Authors
Perisano, Carlo
Marzetti, Emanuele
Graci, Calogero
Maccauro, Giulio
Callà, Cinzia Anna Maria
Spinelli, Maria Silvia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
β-thalassemia major (βTM) or Cooley anemia is characterized by significantly reduced or absent synthesis of β-globin chains, which induces important pathologic consequences including hemolytic anemia, altered erythropoiesis, and bone marrow overstimulation.
The pathogenesis of bone changes in patients with βTM is not yet completely understood.
However, an unbalance in bone mineral turnover resulting from increased resorption and suppression of osteoblast activity has been detected in βTM patients.
The abnormal regulation of bone metabolism may be related to hormonal and genetic factors, iron overload and iron chelation therapy, nutritional deficits, and decreased levels of physical activity.
Here, we review the most recent findings on the physiopathology of bone abnormalities in βTM.
Clinical presentation and radiological features of βTM-related bone changes are also discussed.
American Psychological Association (APA)
Perisano, Carlo& Marzetti, Emanuele& Spinelli, Maria Silvia& Callà, Cinzia Anna Maria& Graci, Calogero& Maccauro, Giulio. 2012. Physiopathology of Bone Modifications in β-Thalassemia. Anemia،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-463295
Modern Language Association (MLA)
Perisano, Carlo…[et al.]. Physiopathology of Bone Modifications in β-Thalassemia. Anemia No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-463295
American Medical Association (AMA)
Perisano, Carlo& Marzetti, Emanuele& Spinelli, Maria Silvia& Callà, Cinzia Anna Maria& Graci, Calogero& Maccauro, Giulio. Physiopathology of Bone Modifications in β-Thalassemia. Anemia. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-463295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463295