Performance of a Whole-Blood Interferon-Gamma Release Assay with Mycobacterium RD1-Specific Antigens among HIV-Infected Persons
Joint Authors
Fujita, Akira
Ajisawa, Atsushi
Harada, Nobuyuki
Mori, Toru
Higuchi, Kazue
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To evaluate the usefulness of one of IGRAs, QuantiFERON-TB Gold (QFT-G), in human immunodeficiency virus- (HIV- ) infected patients with various CD4+ T cell counts.
Methods.
The QFT-G assay was performed using QFT-G kits among 107 HIV-infected patients including 9 cases with active tuberculosis (TB).
Results.
In HIV-infected patients with CD4+>50/μL, QFT-G positive rate for active TB patients was 5/6 (sensitivity =83%), and that for those without active disease was 1/69 (specificity =99%).
The frequency of indeterminate QFT-G test was significantly higher in those with CD4+ less than 50/μL (P<.0001).
At the same time there was a proportional relationship between CD4+ and interferon-gamma response to mitogen (positive control) in QFT-G test (P=.0001).
Conclusions.
Our data suggested that QFT-G had high sensitivity and specificity in HIV-infected populations with CD4+ greater than 50/μL.
However, QFT-G did not perform well in HIV-positive patients with CD4+ less than 50/μL.
American Psychological Association (APA)
Fujita, Akira& Ajisawa, Atsushi& Harada, Nobuyuki& Higuchi, Kazue& Mori, Toru. 2010. Performance of a Whole-Blood Interferon-Gamma Release Assay with Mycobacterium RD1-Specific Antigens among HIV-Infected Persons. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-463626
Modern Language Association (MLA)
Fujita, Akira…[et al.]. Performance of a Whole-Blood Interferon-Gamma Release Assay with Mycobacterium RD1-Specific Antigens among HIV-Infected Persons. Clinical and Developmental Immunology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-463626
American Medical Association (AMA)
Fujita, Akira& Ajisawa, Atsushi& Harada, Nobuyuki& Higuchi, Kazue& Mori, Toru. Performance of a Whole-Blood Interferon-Gamma Release Assay with Mycobacterium RD1-Specific Antigens among HIV-Infected Persons. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-463626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463626