Lipopolysaccharide Animal Models for Parkinson's Disease
Joint Authors
Source
International Journal of Breast Cancer
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lipopolysaccharide (LPS), an endotoxin from Gram-negative bacteria, acts as a potent stimulator of microglia and has been used to study the inflammatory process in the pathogenesis of Parkinson's disease (PD) and anti-inflammatory therapy for PD treatment.
Here, we review the growing body of literature on both in vitro and in vivo LPS PD models.
Primary cell cultures from mesencephalic tissue were exposed to LPS in vitro; LPS was stereotaxically injected into the substantia nigra, striatum, or globus pallidus of brain or injected into the peritoneal cavity of the animal in vivo.
In conclusion, the LPS PD models are summarized as (1) local and direct LPS treatment and (2) systemic LPS treatment.
Mechanisms underlying the PD models are investigated and indicated that LPS induces microglial activation to release a variety of neurotoxic factors, and damaged neurons may trigger reactive microgliosis, which lead to progressive dopaminergic neurodegeneration.
American Psychological Association (APA)
Liu, Mei& Bing, Guoying. 2011. Lipopolysaccharide Animal Models for Parkinson's Disease. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-463793
Modern Language Association (MLA)
Liu, Mei& Bing, Guoying. Lipopolysaccharide Animal Models for Parkinson's Disease. International Journal of Breast Cancer No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-463793
American Medical Association (AMA)
Liu, Mei& Bing, Guoying. Lipopolysaccharide Animal Models for Parkinson's Disease. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-463793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463793