The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus
Joint Authors
Mletzko, Salvinia
Robey, Rebecca C.
Gotch, Frances M.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Kaposi's sarcoma-associated herpesvirus (KSHV) is the aetiological agent of Kaposi's sarcoma (KS), the most frequently arising malignancy in individuals with untreated HIV/AIDS.
There are several lines of evidence to indicate that Kaposi's sarcoma oncogenesis is associated with loss of T-cell-mediated control of KSHV-infected cells.
KSHV can establish life-long asymptomatic infection in immune-competent individuals.
However, when T-cell immune control declines, for example, through AIDS or treatment with immunosuppressive drugs, both the prevalence of KSHV infection and the incidence of KS in KSHV carriers dramatically increase.
Moreover, a dramatic and spontaneous improvement in KS is frequently seen when immunity is restored, for example, through antiretroviral therapy or the cessation of iatrogenic drugs.
In this paper we describe the current state of knowledge on the T-cell immune responses against KSHV.
American Psychological Association (APA)
Robey, Rebecca C.& Mletzko, Salvinia& Gotch, Frances M.. 2011. The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus. Advances in Virology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-464120
Modern Language Association (MLA)
Robey, Rebecca C.…[et al.]. The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus. Advances in Virology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-464120
American Medical Association (AMA)
Robey, Rebecca C.& Mletzko, Salvinia& Gotch, Frances M.. The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus. Advances in Virology. 2011. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-464120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464120