Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis
Joint Authors
Poskerova, Hana
Izakovicova Holla, Lydie
Vokurka, Jan
Borilova Linhartova, Petra
Fassmann, Antonin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
Periodontitis is an inflammatory disease characterized by connective tissue loss and alveolar bone destruction.
Interleukin-8 (IL8) is important in the regulation of the immune response.
The aim of this study was to analyze four polymorphisms in the IL8 gene in relation to chronic (CP) and aggressive (AgP) periodontitis.
Methods.
A total of 492 unrelated subjects were included in this case-control association study.
Genomic DNA of 278 patients with CP, 58 patients with AgP, and 156 controls were genotyped, using the 5′ nuclease TaqMan assay, for IL8 (rs4073, rs2227307, rs2227306, and rs2227532) gene polymorphisms.
Subgingival bacterial colonization was investigated by the DNA-microarray detection kit in a subgroup of subjects (N=247).
Results.
Allele and genotype frequencies of all investigated IL8 polymorphisms were not significantly different between the subjects with CP and/or AgP and controls (P>0.05).
Nevertheless, the A(−251)/T(+396)/T(+781) and T(−251)/G(+396)/C(+781) haplotypes were significantly less frequent in patients with CP (2.0% versus 5.1%, P<0.02, OR = 0.34, 95% CI: 0.15–0.78, resp., 2.0% versus 4.5%, P<0.05, OR = 0.41, 95% CI: 0.18–0.97) than in controls.
Conclusions.
Although none of the investigated SNPs in the IL8 gene was individually associated with periodontitis, some haplotypes can be protective against CP in the Czech population.
American Psychological Association (APA)
Borilova Linhartova, Petra& Vokurka, Jan& Poskerova, Hana& Fassmann, Antonin& Izakovicova Holla, Lydie. 2013. Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464310
Modern Language Association (MLA)
Borilova Linhartova, Petra…[et al.]. Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-464310
American Medical Association (AMA)
Borilova Linhartova, Petra& Vokurka, Jan& Poskerova, Hana& Fassmann, Antonin& Izakovicova Holla, Lydie. Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464310