Role of PPARα and Its Agonist in Renal Diseases
Joint Authors
Lin, Heng
Chen, Hsi-Hsien
Cheng, Ching-Feng
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor (PPAR)-α, a member of a large nuclear receptor superfamily, plays a major role in the regulation of lipid metabolism.
Recently, PPARα activation has been shown to confer additional benefits on endothelial function, kidney function, and anti-inflammation, suggesting that PPARα agonists may be good candidates for treating acute renal failure.
In clinical application, PPAR-α activators, such as hypolipidemic drugs in fibric acid class, were proven to have therapeutic effects on metabolic syndrome and cardiovascular disease.
This paper focuses on signaling pathways, ligand selectivity, and physio-pathological roles of PPARα in kidney diseases and the therapeutic utility of PPARα modulators in the treatment of diabetes and inflammation-induced nephropathy.
Implication of new and more potent PPAR-α activators could provide important insights into the overall benefits of activating PPAR-α clinically for the treatment of dyslipidemia and the prevention of diabetic or inflammation-induced nephropathy in the future.
American Psychological Association (APA)
Cheng, Ching-Feng& Chen, Hsi-Hsien& Lin, Heng. 2010. Role of PPARα and Its Agonist in Renal Diseases. PPAR Research،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-464449
Modern Language Association (MLA)
Cheng, Ching-Feng…[et al.]. Role of PPARα and Its Agonist in Renal Diseases. PPAR Research No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-464449
American Medical Association (AMA)
Cheng, Ching-Feng& Chen, Hsi-Hsien& Lin, Heng. Role of PPARα and Its Agonist in Renal Diseases. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-464449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464449