Evaluation of Clinical and Immunological Responses : A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite
Joint Authors
Gerth van Wijk, Roy
Hendriks, Rudi W.
Moed, Heleen
van der Wouden, J. C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Allergic rhinitis is a disease with polarization towards Th2 and a defect of regulatory T cells.
Immunological changes have been reported after immunotherapy treatment.
However, there is not much known about the natural course of allergic rhinitis with respect to clinical manifestation and the relation with immunological responses.
Objective.
To evaluate clinical symptoms of allergic rhinitis, in relation to in vivo allergen-specific skin responses and in vitro allergen-specific effector and regulatory T cells determined at baseline and after two years.
Methods.
From a large trial, 59 children were randomly selected.
The following variables were compared: clinical symptoms, allergen skin tests, specific IgE, T-cell proliferation, IL-5, IL-13, IFN-gamma, IL-10, TGF-beta, CD4+CD25hi cells, and Foxp3 expression.
Results.
Allergic symptoms had decreased after two years.
Whereas skin test reactions correlated between years 0 and 2, there was no change in the size of the reaction.
Also, proinflammatory reactions did not change after two years, with a positive correlation between years 0 and 2.
No relevant changes were observed with respect to regulatory cells.
Conclusion.
Whereas, comparable to immunotherapy, allergic complaints decrease, the immunological changes of specific T-cell activity (both effector cells and regulator cells) which are observed after immunotherapy, do not change.
American Psychological Association (APA)
Moed, Heleen& Gerth van Wijk, Roy& Hendriks, Rudi W.& van der Wouden, J. C.. 2013. Evaluation of Clinical and Immunological Responses : A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464460
Modern Language Association (MLA)
Moed, Heleen…[et al.]. Evaluation of Clinical and Immunological Responses : A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-464460
American Medical Association (AMA)
Moed, Heleen& Gerth van Wijk, Roy& Hendriks, Rudi W.& van der Wouden, J. C.. Evaluation of Clinical and Immunological Responses : A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464460