Emerging Views on the CTD Code
Joint Authors
Zhang, David W.
Nemec, Corey M.
Rodríguez-Molina, Juan B.
Ansari, Aseem Z.
Tietjen, Joshua R.
Source
Genetics Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-26
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
The C-terminal domain (CTD) of RNA polymerase II (Pol II) consists of conserved heptapeptide repeats that function as a binding platform for different protein complexes involved in transcription, RNA processing, export, and chromatin remodeling.
The CTD repeats are subject to sequential waves of posttranslational modifications during specific stages of the transcription cycle.
These patterned modifications have led to the postulation of the “CTD code” hypothesis, where stage-specific patterns define a spatiotemporal code that is recognized by the appropriate interacting partners.
Here, we highlight the role of CTD modifications in directing transcription initiation, elongation, and termination.
We examine the major readers, writers, and erasers of the CTD code and examine the relevance of describing patterns of posttranslational modifications as a “code.” Finally, we discuss major questions regarding the function of the newly discovered CTD modifications and the fundamental insights into transcription regulation that will necessarily emerge upon addressing those challenges.
American Psychological Association (APA)
Zhang, David W.& Rodríguez-Molina, Juan B.& Tietjen, Joshua R.& Nemec, Corey M.& Ansari, Aseem Z.. 2012. Emerging Views on the CTD Code. Genetics Research International،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-464630
Modern Language Association (MLA)
Zhang, David W.…[et al.]. Emerging Views on the CTD Code. Genetics Research International No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-464630
American Medical Association (AMA)
Zhang, David W.& Rodríguez-Molina, Juan B.& Tietjen, Joshua R.& Nemec, Corey M.& Ansari, Aseem Z.. Emerging Views on the CTD Code. Genetics Research International. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-464630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464630