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The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course
Joint Authors
Kullak-Ublick, Gerd A.
Eloranta, Jyrki J.
Grete-Wenger, Christa
Mwinyi, Jessica
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation.
We aimed at determining the occurring PPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in inflammatory bowel disease (IBD) patients in comparison with healthy controls.
We determined genetic variants in the coding exons and flanking intronic sequences of the NR1C3 gene in 284 IBD patients and 194 controls and predicted NR1C3 haplotypes via bioinformatic analysis.
We investigated whether certain NR1C3 variants are associated with susceptibility to IBD or its disease course.
None of the detected 22 NR1C3 variants were associated with IBD.
Two variants with allelic frequencies over 1% were included in haplotype/diplotype analyses.
None of the NR3C1 haplotypes showed association with IBD development or disease course.
We conclude that NR1C3 haplotypes are not related to IBD susceptibility or IBD disease activity.
American Psychological Association (APA)
Mwinyi, Jessica& Grete-Wenger, Christa& Eloranta, Jyrki J.& Kullak-Ublick, Gerd A.. 2012. The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course. PPAR Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-464836
Modern Language Association (MLA)
Mwinyi, Jessica…[et al.]. The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course. PPAR Research No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-464836
American Medical Association (AMA)
Mwinyi, Jessica& Grete-Wenger, Christa& Eloranta, Jyrki J.& Kullak-Ublick, Gerd A.. The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-464836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464836