RASRAFMEKERK and PI3KPTENAKT Signaling in Malignant Melanoma Progression and Therapy
Joint Authors
Yamanoshita, Osamu
Takeda, Kozue
Goto, Yuji
Kumasaka, Mayuko Y.
Iida, Machiko
Yajima, Ichiro
Tamura, Haruka
Kawamoto, Yoshiyuki
Ohgami, Nobutaka
Kato, Masashi
Thang, Nguyen Dinh
Source
Dermatology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy.
Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of melanocytes.
In human melanomas, the RAS/RAF/MEK/ERK (MAPK) and the PI3K/PTEN/AKT (AKT) signaling pathways are two major signaling pathways and are constitutively activated through genetic alterations.
Mutations of RAF, RAS, and PTEN contribute to antiapoptosis, abnormal proliferation, angiogenesis, and invasion for melanoma development and progression.
To find better approaches to therapies for patients, understanding these MAPK and AKT signaling mechanisms of melanoma development and progression is important.
Here, we review MAPK and AKT signaling networks associated with melanoma development and progression.
American Psychological Association (APA)
Yajima, Ichiro& Kumasaka, Mayuko Y.& Thang, Nguyen Dinh& Goto, Yuji& Takeda, Kozue& Yamanoshita, Osamu…[et al.]. 2011. RASRAFMEKERK and PI3KPTENAKT Signaling in Malignant Melanoma Progression and Therapy. Dermatology Research and Practice،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-465284
Modern Language Association (MLA)
Yajima, Ichiro…[et al.]. RASRAFMEKERK and PI3KPTENAKT Signaling in Malignant Melanoma Progression and Therapy. Dermatology Research and Practice No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-465284
American Medical Association (AMA)
Yajima, Ichiro& Kumasaka, Mayuko Y.& Thang, Nguyen Dinh& Goto, Yuji& Takeda, Kozue& Yamanoshita, Osamu…[et al.]. RASRAFMEKERK and PI3KPTENAKT Signaling in Malignant Melanoma Progression and Therapy. Dermatology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-465284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465284