The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis
Joint Authors
Zhang, Hong-Liang
Zhu, Jie
Wu, Jiang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Apolipoprotein E (apoE) is a 34.2 kDa glycosylated protein characterized by its wide tissue distribution and multiple functions.
ApoE has been widely studied in lipid metabolism, cardiocerebrovascular diseases, and neurodegenerative diseases like Alzheimer's disease and mild cognitive impairment, and so forth.
Recently, a growing body of evidence has pointed to nonlipid related properties of apoE, including suppression of T cell proliferation, regulation of macrophage function, facilitation of lipid antigen presentation by CD1 molecules to natural killer T (NKT) cells, and modulation of inflammation and oxidation.
By these properties, apoE impacts physiology and pathophysiology at multiple levels.
The present paper summarizes updated studies on the immunoregulatory function of apoE, with special focus on isoform-specific effects of apoE on Guillain-Barré syndrome (GBS) and its animal model experimental autoimmune neuritis (EAN).
American Psychological Association (APA)
Zhang, Hong-Liang& Wu, Jiang& Zhu, Jie. 2010. The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-465528
Modern Language Association (MLA)
Zhang, Hong-Liang…[et al.]. The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-465528
American Medical Association (AMA)
Zhang, Hong-Liang& Wu, Jiang& Zhu, Jie. The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-465528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465528