The Role of TPA ID and PAI-1 4G5G Polymorphisms in Multiple Sclerosis
Joint Authors
Sinanović, Osman
Sepčić, Juraj
Stanković, Aleksandra
Gašparović, Iva
Klupka-Sarić, Inge
Kapović, Miljenko
Peterlin, Borut
Lovrečić, Luca
Dinčić, Evica
Stojković, Ljiljana
Rudolf, Gorazd
Starčević Čizmarević, Nada
Lavtar, Polona
Ristić, Smiljana
Šega Jazbec, Saša
Perković, Olivio
Živković, Maja
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Previous studies have shown impaired fibrinolysis in multiple sclerosis (MS) and implicated extracellular proteolytic enzymes as important factors in demyelinating neuroinflammatory disorders.
Tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) are key molecules in both fibrinolysis and extracellular proteolysis.
In the present study, an association of the TPA Alu I/D and PAI-1 4G/5G polymorphisms with MS was analyzed within the Genomic Network for Multiple Sclerosis (GENoMS).
Methods.
The GENoMS includes four populations (Croatian, Slovenian, Serbian, and Bosnian and Herzegovinian) sharing the same geographic location and a similar ethnic background.
A total of 885 patients and 656 ethnically matched healthy blood donors with no history of MS in their families were genotyped using PCR-RFLP.
Results.
TPA DD homozygosity was protective (OR = 0.79, 95% CI 0.63–0.99, P=0.037) and PAI 5G5G was a risk factor for MS (OR = 1.30, 95% CI 1.01–1.66, P=0.038).
A significant effect of the genotype/carrier combination was detected in 5G5G/I carriers (OR = 1.39 95% CI 1.06–1.82, P=0.017).
Conclusions.
We found a significantly harmful effect of the combination of the PAI-1 5G/5G genotype and TPA I allele on MS susceptibility, which indicates the importance of gene-gene interactions in complex diseases such as MS.
American Psychological Association (APA)
Živković, Maja& Starčević Čizmarević, Nada& Lovrečić, Luca& Klupka-Sarić, Inge& Stanković, Aleksandra& Gašparović, Iva…[et al.]. 2014. The Role of TPA ID and PAI-1 4G5G Polymorphisms in Multiple Sclerosis. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-466010
Modern Language Association (MLA)
Živković, Maja…[et al.]. The Role of TPA ID and PAI-1 4G5G Polymorphisms in Multiple Sclerosis. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-466010
American Medical Association (AMA)
Živković, Maja& Starčević Čizmarević, Nada& Lovrečić, Luca& Klupka-Sarić, Inge& Stanković, Aleksandra& Gašparović, Iva…[et al.]. The Role of TPA ID and PAI-1 4G5G Polymorphisms in Multiple Sclerosis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-466010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466010