β-Secretases, Alzheimer’s Disease, and Down Syndrome
Joint Authors
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Individuals with Down Syndrome (DS), or trisomy 21, develop Alzheimer’s disease (AD) pathology by approximately 40 years of age.
Chromosome 21 harbors several genes implicated in AD, including the amyloid precursor protein and one homologue of the β-site APP cleaving enzyme, BACE2.
Processing of the amyloid precursor protein by β-secretase (BACE) is the rate-limiting step in the production of the pathogenic Aβ peptide.
Increased amounts of APP in the DS brain result in increased amounts of Aβ and extracellular plaque formation beginning early in life.
BACE dysregulation potentially represents an overlapping biological mechanism with sporadic AD and a common therapeutic target.
As the lifespan for those with DS continues to increase, age-related concerns such as obesity, depression, and AD are of growing concern.
The ability to prevent or delay the progression of neurodegenerative diseases will promote healthy aging and improve quality of life for those with DS.
American Psychological Association (APA)
Webb, Robin L.& Murphy, M. Paul. 2012. β-Secretases, Alzheimer’s Disease, and Down Syndrome. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-466023
Modern Language Association (MLA)
Webb, Robin L.& Murphy, M. Paul. β-Secretases, Alzheimer’s Disease, and Down Syndrome. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-466023
American Medical Association (AMA)
Webb, Robin L.& Murphy, M. Paul. β-Secretases, Alzheimer’s Disease, and Down Syndrome. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-466023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466023