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NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis
Author
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is the third largest cause of cancer deaths worldwide.
The role of molecular changes in HCC have been used to identify prognostic markers and chemopreventive or therapeutic targets.
It seems that toll-like receptors (TLRs) as well as the nuclear factor (NF)-κB, and JNK pathways are critical regulators for the production of the cytokines associated with tumor promotion.
The cross-talk between an inflammatory cell and a neoplastic cell, which is instigated by the activation of NF-κB and JNKs, is critical for tumor organization.
JNKs also regulate cell proliferation and act as oncogenes, making them the main tumor-promoting protein kinases.
TLRs play roles in cytokine and hepatomitogen expression mainly in myeloid cells and may promote liver tumorigenesis.
A better understanding of these signaling pathways in the liver will help us understand the mechanism of hepatocarcinogenesis and provide a new therapeutic target for HCC.
American Psychological Association (APA)
Maeda, Shin. 2010. NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-466385
Modern Language Association (MLA)
Maeda, Shin. NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis. Gastroenterology Research and Practice No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-466385
American Medical Association (AMA)
Maeda, Shin. NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-466385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466385