Lack of Association between Recurrent Pregnancy Loss and Inherited Thrombophilia in a Group of Colombian Patients
Joint Authors
Tobón, Luis
Cardona Maya, Wálter
Torres, José
Cadavid, Ángela P.
Cardona, Henry
Gómez, Joaquín
Castañeda, Serguei A.
Bedoya, Gabriel
Alvarez, Leonor
Gómez, Jorge
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Studies have shown an association between recurrent pregnancy loss and inherited thrombophilia in Caucasian populations, but there is insufficient knowledge concerning triethnic populations such as the Colombian.
The aim of this study was to evaluate whether inherited thrombophilia is associated with recurrent pregnancy loss.
Methods.
We conducted a case-control study of 93 patients with recurrent pregnancy loss (cases) and 206 healthy multiparous women (controls) in a Colombian subpopulation.
Three single nucleotide polymorphisms (SNPs) markers of the inherited thrombophilias factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T were genotyped by PCR-RFLP.
Activated protein C resistance and plasma levels of antithrombin, protein C, and protein S were also measured.
Results.
The frequency of thrombophilia-associated SNPs, activated protein C resistance, and anticoagulant protein deficiencies, was low overall, except for the methylenetetrahydrofolate reductase C677T SNP.
The differences between patients and controls had no statistical significance.
Conclusion.
Our study confirms the low prevalence of inherited thrombophilias in non-Caucasian populations and it is unlikely that the tested thrombophilias play a role in the pathogenesis of recurrent pregnancy loss in this Colombian population.
American Psychological Association (APA)
Cardona, Henry& Castañeda, Serguei A.& Cardona Maya, Wálter& Alvarez, Leonor& Gómez, Joaquín& Gómez, Jorge…[et al.]. 2012. Lack of Association between Recurrent Pregnancy Loss and Inherited Thrombophilia in a Group of Colombian Patients. Thrombosis،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-466389
Modern Language Association (MLA)
Cardona, Henry…[et al.]. Lack of Association between Recurrent Pregnancy Loss and Inherited Thrombophilia in a Group of Colombian Patients. Thrombosis No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-466389
American Medical Association (AMA)
Cardona, Henry& Castañeda, Serguei A.& Cardona Maya, Wálter& Alvarez, Leonor& Gómez, Joaquín& Gómez, Jorge…[et al.]. Lack of Association between Recurrent Pregnancy Loss and Inherited Thrombophilia in a Group of Colombian Patients. Thrombosis. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-466389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466389