Kölliker’s Organ and the Development of Spontaneous Activity in the Auditory System : Implications for Hearing Dysfunction
Joint Authors
Thorne, Peter R.
Lipski, Janusz
Dayaratne, M. W. Nishani
Vlajkovic, Srdjan M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Prior to the “onset of hearing,” developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is thought to be important in retaining and refining neural connections in the absence of sound.
One of the major hypotheses regarding the origin of such activity involves a group of columnar epithelial supporting cells forming Kölliker’s organ, which is only present during this critical period of auditory development.
There is strong evidence for a purinergic signalling mechanism underlying such activity.
ATP released through connexin hemichannels may activate P2 purinergic receptors in both Kölliker’s organ and the adjacent IHCs, leading to generation of electrical activity throughout the auditory system.
However, recent work has suggested an alternative origin, by demonstrating the ability of IHCs to generate this spontaneous activity without activation by ATP.
Regardless, developmental abnormalities of Kölliker’s organ may lead to congenital hearing loss, considering that mutations in ion channels (hemichannels, gap junctions, and calcium channels) involved in Kölliker’s organ activity share strong links with such types of deafness.
American Psychological Association (APA)
Dayaratne, M. W. Nishani& Vlajkovic, Srdjan M.& Lipski, Janusz& Thorne, Peter R.. 2014. Kölliker’s Organ and the Development of Spontaneous Activity in the Auditory System : Implications for Hearing Dysfunction. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-466404
Modern Language Association (MLA)
Dayaratne, M. W. Nishani…[et al.]. Kölliker’s Organ and the Development of Spontaneous Activity in the Auditory System : Implications for Hearing Dysfunction. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-466404
American Medical Association (AMA)
Dayaratne, M. W. Nishani& Vlajkovic, Srdjan M.& Lipski, Janusz& Thorne, Peter R.. Kölliker’s Organ and the Development of Spontaneous Activity in the Auditory System : Implications for Hearing Dysfunction. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-466404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466404