Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis
Joint Authors
Edukulla, Ramakrishna
Kerkvliet, Jason
Rodriguez, Moses
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The RNA-dependent RNA-polymerase, 3Dpol, is an essential component in the picornavirus genome for the replication of single stranded RNA.
However, transgenic expression of 3Dpol in mice has antiviral effects.
Here, we discuss the structure and function of 3Dpol during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in 3Dpol after picornavirus infection, highlight data showing the antiviral effects of transgenic 3Dpol from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which 3Dpol is causing this antiviral effect in mice.
American Psychological Association (APA)
Kerkvliet, Jason& Edukulla, Ramakrishna& Rodriguez, Moses. 2010. Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis. Advances in Virology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-466415
Modern Language Association (MLA)
Kerkvliet, Jason…[et al.]. Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis. Advances in Virology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-466415
American Medical Association (AMA)
Kerkvliet, Jason& Edukulla, Ramakrishna& Rodriguez, Moses. Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis. Advances in Virology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-466415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466415