Tannic Acid Preferentially Targets Estrogen Receptor-Positive Breast Cancer
Joint Authors
Park, Jang Pyo
Burg, Karen J. L.
Inskeep, Beau D.
Hay, Elizabeth J.
Shah, Hiral
Booth, Brian W.
Source
International Journal of Breast Cancer
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Research efforts investigating the potential of natural compounds in the fight against cancer are growing.
Tannic acid (TA) belongs to the class of hydrolysable tannins and is found in numerous plants and foods.
TA is a potent collagen cross-linking agent; the purpose of this study was to generate TA-cross-linked beads and assess the effects on breast cancer cell growth.
Collagen beads were stable at body temperature following crosslinking.
Exposure to collagen beads with higher levels of TA inhibited proliferation and induced apoptosis in normal and cancer cells.
TA-induced apoptosis involved activation of caspase 3/7 and caspase 9 but not caspase 8.
Breast cancer cells expressing the estrogen receptor were more susceptible to the effects of TA.
Taken together the results suggest that TA has the potential to become an anti-ER+ breast cancer treatment or preventative agent.
American Psychological Association (APA)
Booth, Brian W.& Inskeep, Beau D.& Shah, Hiral& Park, Jang Pyo& Hay, Elizabeth J.& Burg, Karen J. L.. 2013. Tannic Acid Preferentially Targets Estrogen Receptor-Positive Breast Cancer. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-466585
Modern Language Association (MLA)
Booth, Brian W.…[et al.]. Tannic Acid Preferentially Targets Estrogen Receptor-Positive Breast Cancer. International Journal of Breast Cancer No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-466585
American Medical Association (AMA)
Booth, Brian W.& Inskeep, Beau D.& Shah, Hiral& Park, Jang Pyo& Hay, Elizabeth J.& Burg, Karen J. L.. Tannic Acid Preferentially Targets Estrogen Receptor-Positive Breast Cancer. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-466585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466585