Inhibitory Effects of Edaravone in β-Amyloid-Induced Neurotoxicity in Rats
Joint Authors
He, Feng
Xiao, Song-Hua
Che, Feng-Yuan
Liu, Jun
Yang, Lian-Hong
Cao, Yan-Ping
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Amyloid protein can damage nerve cells through a variety of biological mechanisms including oxidative stress, alterations in calcium homeostasis, and proapoptosis.
Edaravone, a potent free radical scavenger possessing antioxidant effects, has been proved neuroprotective effect in stroke patients.
The current study aimed to investigate the effects of EDA in an Aβ-induced rat model of AD, by studying Aβ1–40-induced voltage-gated calcium channel currents in hippocampal CA1 pyramidal neurons, learning and memory behavioral tests, the number of surviving cholinergic neurons in the basal forebrain, and the acetylcholine level in the hippocampus in this rat model of AD.
The results showed that the Aβ1–40-induced increase of ICa can be inhibited by EDA in a dose-dependent manner.
Treatment with EDA significantly improved Aβ1–40-induced learning and memory performance.
Choline acetyltransferase positive cells in basal forebrain and acetylcholine content in the hippocampus were increased by the administration of EDA as compared with the non-EDA treated Aβ1–40 group.
These results demonstrate that EDA can inhibit the neurotoxic effect of Aβ toxicity.
Collectively, these findings suggest that EDA may serve as a potential complemental treatment strategy for AD.
American Psychological Association (APA)
He, Feng& Cao, Yan-Ping& Che, Feng-Yuan& Yang, Lian-Hong& Xiao, Song-Hua& Liu, Jun. 2014. Inhibitory Effects of Edaravone in β-Amyloid-Induced Neurotoxicity in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-466648
Modern Language Association (MLA)
He, Feng…[et al.]. Inhibitory Effects of Edaravone in β-Amyloid-Induced Neurotoxicity in Rats. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-466648
American Medical Association (AMA)
He, Feng& Cao, Yan-Ping& Che, Feng-Yuan& Yang, Lian-Hong& Xiao, Song-Hua& Liu, Jun. Inhibitory Effects of Edaravone in β-Amyloid-Induced Neurotoxicity in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-466648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466648